Synthesis, spectroscopicand antimicrobial activityof some new 7-methyl-2- phenylimidazo[1,2-a]pyridin-3-amine derivatives
نویسندگان
چکیده
The new series of Schiff base were synthesized from 7-methyl-2-phenylimidazo[1,2-a]pyridin-3-amine condensed with different substituted aldehydes (4-Hydroxybenzaldehyde, Vanillin, 3-Nitrobenzaldyde, 4Nitrobenzaldehyde)in presence of catalytic quantities of acetic acid. So the structure offers for this synthesis well coincide with the results obtained bydifferent spectroscopic techniques (IR, 1 H NMR, 13 C NMR and Mass spectroscopy). These new compounds were evaluated for their antibacterial, againstGram positive and Gram negative bacteria, and antifungal activityagainst yeasts and moulds, using micro-dilution tests. The biological activityof the synthesized compoundswere compared with standard drugs. The best results are observed in the amine starting (new 7-methyl-2-phenylimidazo [1,2-a]pyridin-3-amine), it showed interesting antibacterial activity of all tested strains, particularly against Proteus strain is a Gram -.
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